Depression
Conditions
Interventions
Treatment group:Antidepressant drugs combined with probiotics for treatment
Control group:Antidepressant drugs plus placebo treatment
Sponsors
Huzhou Third People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with depression by ICD-10 criteria by two or more attending physicians; 2. Age 18-60 years old; 3. I or his agent sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Combined with malignant tumor; 2. The patient has a history of use of antibiotics, hormones, or intestinal microbiotics within 3 months before admission; 3. Patients with severe diarrhea or constipation; 4. Abuse of psychoactive substances; 5. Acute or chronic diseases (including stroke, epilepsy, high blood pressure, endocrine disease, diabetes, fatty liver disease or severe cardiovascular disease); 6. Co-existing neurological or physical diseases confirmed by detailed medical examination, in particular neurological examination, routine blood tests and computed tomography of the brain (if necessary); 7. A specific diet, such as a weight loss diet or one based entirely on vegetables; 8. Specific treatment within 6 months, such as transcranial magnetic stimulation or electroconvulsive therapy; 9. Pregnancy, breastfeeding; 10. There are obvious abnormalities in physical examination, neurological examination or blood routine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton's Depression Scale(HAMD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Psychosomatic Symptom Scale (PSSS);Patient Health Questionnaire -9 Items (PHQ-9);TESS Scale;Sequencing of intestinal microbial genes;Cytokines such as interleukins, interferons, and tumor necrosis factors; | — |
Countries
China
Contacts
Public ContactShen zhongxia
Huzhou Third People's Hospital
Outcome results
None listed