thyroid surgery
Conditions
Interventions
Oxyramine group (Group O):2 mg of oxyramine was administered to the patient 30 minutes before the surgery was completed.
Esketamine group (Group E):0.25 mg/kg of esketamine was administered to the patient 30 minutes before the surgery was completed.
Sponsors
Anqing Municipal Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 - 65 years old; 2. BMI: 18 - 30 kg/m²; 3. ASA grade I - III; 4. Patients planning to undergo elective thyroidectomy under general anesthesia; 5. Normal communication and interaction; 6. Voluntary participants and having signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe hypertension; 2. Patients diagnosed with sleep apnea; 3. Patients with a history of allergy to opioids or esketamine and those with contraindications to opioids or esketamine; 4. Long-term use of opioid treatment; 5. Abnormal electrocardiogram (during screening, QTc F interval > 470 ms); 6. Patients with mental disorders; 7. Patients with impaired liver and kidney function; 8. Pregnant or lactating women; 9. Patients with a high risk of intracranial pressure increase.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of coughing reflex during extubation; | — |
Secondary
| Measure | Time frame |
|---|---|
| The severity of the choking and coughing reactions during tube removal;Postoperative pain NRS score;Postoperative sore throat and dry throat;Post-operative hoarseness;When the anesthetic drugs are stopped being administered, when consciousness returns and the eyes are opened cooperatively, during extubation, 1 minute after extubation, 5 minutes after extubation, he;Awakening time; Tube removal time;Adverse reactions during the stay in the PACU; | — |
Countries
China
Contacts
Public ContactWu Xiongzhi
Anqing Municipal Hospital
Outcome results
None listed