Paresthesia
Conditions
Interventions
Trial group (DEX group):Dexmedetomidine 0.5 µg/kg, intravenous infusion over 10 minutes
Control group (C group):Normal saline, intravenous infusion over 10 minutes
Sponsors
Obstetrics and Gynecology Hospital of Fudan University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old; 2. ASA I-II grade; 3. BMI 18.5-29.9kg/m^2; 4. The alkaline phosphatase value (ALP) is within the normal range.
Exclusion criteria
Exclusion criteria: 1. Pregnant and lactating women; 2. Preoperative heart rate<50 beats per minute; 3. Sick sinus syndrome; 4. Second degree and above atrioventricular block; 5. Moderate to severe abnormalities in liver and kidney function; 6. Existence of heart or respiratory system diseases; 7. History of drug abuse or alcohol dependence; 8. Long term history of taking sedatives or analgesics; 9. Individuals who are allergic or have contraindications to experimental drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of abnormal sensations; | — |
Secondary
| Measure | Time frame |
|---|---|
| Onset time of propofol disodium phosphate;Severity of abnormal sensations;Adverse events during induction period;Intraoperative parameters;Recovery quality;Adverse events in PACU; | — |
Countries
China
Contacts
Public ContactMa Li
Obstetrics and Gynecology Hospital of Fudan University
Outcome results
None listed