Hilar Cholangiocarcinoma
Conditions
Interventions
Observation group:None
Control group:None
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Generally good preoperative condition without significant dysfunction of vital organs including the brain, heart, lung, kidney and others 2.Preoperative imaging demonstrates a hilar mass or intrahepatic cholangiocarcinoma invading the hepatic hilum 3.No primary malignant tumor in other systems and no distant metastasis 4.Surgical procedures are radical resection of hilar cholangiocarcinoma with combined vascular resection and reconstruction, and radical resection without vascular resection and reconstruction 5.Postoperative pathology confirms cholangiocarcinoma
Exclusion criteria
Exclusion criteria: 1.Presence of surgical contraindications such as widespread systemic metastasis 2.Eastern Cooperative Oncology Group (ECOG) performance status score = 3, unable to tolerate general anesthesia 3.Patients refusing surgical treatment 4.Involvement of secondary or higher branches of bilateral intrahepatic bile ducts 5.Intrahepatic dissemination, peritoneal metastasis, or distant organ metastasis 6.Concurrent involvement of both left and right portal vein branches or bilateral hepatic arteries, with residual liver blood supply unable to be restored by vascular reconstruction
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of severe complications (Clavien?Dindo grade = IIIa) during the perioperative period; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative biliary leakage rate;Specific postoperative complications included pancreatic fistula, biliary fistula, gastrointestinal anastomotic leakage, intra-abdominal infection, and abdominal cavity Bleeding, pulmonary infection, incision infection, etc;All-cause mortality rates at 30 days and 90 days after the surgery;Intraoperative indicators: operation time, intraoperative blood loss, intraoperative blood transfusion rate;Postoperative recovery indicators included first exhaust time, first feeding time, postoperative hospital stay, ICU admission rate and length of stay.;Oncology indicators included R0 resection rate, number of lymph node dissection and number of positive lymph nodes;Long-term prognosis: disease-free survival (DFS), overall survival (OS); | — |
Countries
China
Contacts
Public ContactZhang Wen
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed