Pulmonary fibrosis
Conditions
Interventions
The non-cadmium-exceeding observation group:None
Group with excessive cadmium content:None
Healthy Control Group:None
Sponsors
Beijing Chao-Yang Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years old. 2.Diagnosed with pulmonary fibrosis (including idiopathic pulmonary fibrosis, connective tissue disease-related interstitial lung disease) in accordance with international guidelines. 3.Signed an informed consent form and was willing to undergo follow-up. 4.Capable of providing feasible urine and blood samples for testing.
Exclusion criteria
Exclusion criteria: 1.Severe hepatic or renal dysfunction that may affect heavy metal metabolism. 2.Received chelating agent or metal ion intervention therapy within the recent 3 months. 3.Complicated with active malignant tumor or acute pulmonary infection. 4.Unable to cooperate with follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Annual Decline Rate of FVC%pred;Overall Survival (OS);Time to Progression (TTP); | — |
Secondary
| Measure | Time frame |
|---|---|
| HRCT Imaging Changes;Hospitalization Times and Causes;Incidence of Acute Exacerbation;Dynamic Changes of Inflammatory and Fibrotic Biomarkers; | — |
Countries
China
Contacts
Public ContactQiao Ye
Beijing Chao-Yang Hospital, Capital Medical University
Outcome results
None listed