Parkinson's disease
Conditions
Interventions
Experimental group:Transcranial magnetic stimulation treatment guided by individual brain functional segmentation technology
Sponsors
Jinan Central Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age should be no more than 75 years old; 2. Meet the diagnostic criteria of the International Parkinson's Disease Society in 2015 and be diagnosed with Parkinson's disease; 3. Hoehn-Yahr staging is between 1 and 3 (during the "off" period of medication); 4. Have received stable anti-PD medication treatment for at least 1 month; 5. Can understand the research content and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Those with a history of stroke or other brain organic diseases; 2. PD patients with persistent head tremors that affect the accuracy of optical navigation tracking; 3. Those with significant cognitive impairment affecting cooperation (MMSE <= 20 points, relaxed to meet the characteristics of the real world compared to the RCT protocol); 4. Those who have previously undergone DBS surgery; 5. Those with contraindications to MRI or TMS treatment (such as claustrophobia, cardiac pacemaker, internal metal implants, history of epilepsy attacks, etc.); 6. Pregnant women and women in the pregnancy period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unified Parkinson's Disease Rating Scale (UPDRSIII) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini Mental State Examination (MMSE) score;Hamilton Depression Scale score;Duration of drug action;Unified Parkinson's Disease Rating Scale (UPDRSI II IV) score;Montreal Cognitive Assessment;Freezing Gait Questionnaire;Wexner Constipation Score;Pittsburgh Sleep Quality Index Survey Form score;a-synuclein;Change in network connection strength (FC);Functional indicators of lymphoid structures; | — |
Countries
China
Contacts
Public ContactSu Daoqing;Zhang Xiaohua
Jinan Central Hospital
Outcome results
None listed