Hematologic malignancies
Conditions
Interventions
Gold Standard:1. Central nervous system signs, especially increased intracranial pressure
2. CSF changes: (1) Intracranial pressure > 200 mmH2O
(2) WBC > 0.01 × 10^9/L
(3) leukemia cells on smear
(4) protein > 0.45 g/L or positive qualitative test
3. Other causes of similar CNS or CSF changes excluded.
Index test:Cerebrospinal fluid cytokine levels, indicators including: IL-1ß, IL-2, IL-2R, IL-4, IL-5, IL-6, IL-8, IL-10, TNF-a, IFN-?, IFN-a, IL-12p70, IL-17.
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Confirmed diagnosis of hematologic malignancy; 2. Requirement for cerebrospinal fluid (CSF) collection based on clinical indications.
Exclusion criteria
Exclusion criteria: 1. Non-lymphoid related nervous system tumors; 2. Central nervous system diseases of immune, infectious, or traumatic origin.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebrospinal fluid cytokines (IL-1ß, IL-2, etc.);sensitivity;specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quantitative analysis of cerebrospinal fluid protein;Cerebrospinal fluid abnormal cell ratio;Cerebrospinal fluid glucose;cerebrospinal fluid chloride;Flow cytometry immunophenotyping;Cerebrospinal fluid white blood cell count;Chromosome karyotyping;Receiver operating characteristic curve (ROC);Fusion gene;Morphological analysis of bone marrow smear cells; | — |
Countries
China
Contacts
Public ContactXia Peng
Shanghai General Hospital
Outcome results
None listed