Patients with digestive system diseases who need painless gastroscopy
Conditions
Interventions
Youth group 18-44 years old:This study employed the modified Dixon sequential method to measure the half-maximal effective dose of the drug. If the gastroscopy insertion response was positive, the dos
if the gastroscopy insertion response was negative, the dose of the next case of tizoxanide was decreased by one concentration gradient. The case number and dose corresponding to the positive gastrosc
Middle-aged group (45-64 years :This study employed the modified Dixon sequential method to measure the half-maximal effective dose of the drug. If the gastroscopy insertion response was positive, the
if the gastroscopy insertion response was negative, the dose of the next
Sponsors
Xianyang Central Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years old; 2. ASA physical status I-II; 3. BMI 18-30 kg/m^2; 4. Patients undergoing gastroscopy under sedation anesthesia at an elective time.
Exclusion criteria
Exclusion criteria: 1. Refusal to sign the informed consent form; 2. Expected difficult airway; 3. Known allergy to the drugs and components used in this study; 4. Known or suspected gastrointestinal obstruction; 5. Acute or severe bronchial asthma; 6. Severe hepatic and renal insufficiency; 7. Long-term use of opioids.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED50 and ED95; | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate (HR), oxygen saturation (SpO2), and mean arterial pressure (MAP);Number of airway assistance procedures;Number of endoscopy withdrawals due to persistent hypoxemia;Frequency and duration of dizziness, nausea, and vomiting;Patient and endoscopist satisfaction;Dose of cycloprofen for induction and total administration, dose of tigecycline, time to successful induction, duration of endoscopy (from insertion to removal of endoscope), and use of vasopressor agents; | — |
Countries
China
Contacts
Public ContactWang Yu
Xianyang Central Hospital
Outcome results
None listed