Perioperative anxiety
Conditions
Interventions
Esketamine group(E):At the beginning of the anesthesia induction, eszopiclone was intravenously infused (0.5 mg/kg, diluted to 20 mL, with a pumping time of 20 minutes)
Control group(C):Intravenous infusion of an equal volume (over 20 minutes) of normal saline
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients diagnosed with vulvar leukoplakia and scheduled for focused ultrasound treatment; 2.aged between 18 and 65 years; 3.with ASA classification of I-III; 4.and who have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Those with contraindications or allergies to esketamine or other study drugs; 2.those with preoperative mental disorders (such as moderate to severe depression, obsessive-compulsive disorder, etc.) or cognitive impairments; 3. those with severe liver or kidney dysfunction; 4.pregnant women or lactating women, and those who cannot cooperate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale (HAMA) scores at 1, 3, 7 and 30 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anxiety levels at 1, 3, 7 and 30 days after surgery;Depression levels at 1, 3, 7 and 30 days after surgery;Pain levels at 1, 3, 7 and 30 days after the operation;Postoperative recovery quality at 1, 3, 7 and 30 days;Sleep quality 30 days after surgery;The levels of plasma BDNF, cortisol and IL-6 within 24 hours after the operation;Vital signs;Dosage of anesthetic drugs;Anesthesia Surgery Information;Incidence of adverse events; | — |
Countries
China
Contacts
Public ContactQilin Liu
Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed