Postoperative nausea and vomiting
Conditions
Interventions
Palonosetron group:Palonosetron combined with dexamethasone for the prevention of postoperative nausea and vomiting
Aprepitant group:Aprepitant combined with dexamethasone for the prevention of postoperative nausea and vomiting
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age between 20 and 80 years old; 2.Patients scheduled for gynecological laparoscopic surgery; 3.Risk score for postoperative nausea and vomiting (Apfel score) >=3 points (high risk);
Exclusion criteria
Exclusion criteria: 1.ASA classification IV and above; 2.Patients who have experienced cardiovascular or cerebrovascular events within the past 3 months, have unstable blood pressure control, severe liver or kidney dysfunction, and those using warfarin, bimosit, ketoconazole, or rifampin before surgery; 3.Cognitive impairment prevents cooperation; 4.Transitional laparotomy; 5.Use of other antiemetic drugs or allergy to the study drug within 48 hours before surgery; 6.Pregnant women, breastfeeding women, or those planning to use hormonal contraceptives within one month after surgery;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete remission rate (CRR) of PONV in subjects; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time of first nausea or vomiting;Severity of nausea and vomiting;Postoperative nausea and vomiting satisfaction score of the subjects;15 Recovery Quality Scoring System;Occurrence of Adverse Reactions;Pain score (static and dynamic);Rescue antiemetic drug usage rate; | — |
Countries
China
Contacts
Public ContactHua Zhen
Beijing Hospital
Outcome results
None listed