Diabetes
Conditions
Interventions
Lingnan Dietary Group (Standardized Lingnan Diet):On weekdays (Monday to Friday) and Saturdays, three meals per day are uniformly prepared and delivered by a central kitchen. The diet provided has an
Conventional Diet Control Group (Conventional Healthy Diet Education):Content: At baseline, participants receive a one?time standardized healthy diet education (based on the Expert Consensus on Clinic
participants only weigh and record daily food intake and upload records via WeChat. Equal attention is given through a WeChat group and weekly phone calls to check dietary records, without providing s
Sponsors
Guangdong Provincial Center for Disease Control and Prevention
Eligibility
Sex/Gender
All
Age
40 Years to 59 Years
Inclusion criteria
Inclusion criteria: (1) Aged 40–59 years, both genders; and length of residence in the Lingnan region (Guangdong, Guangxi, Hainan, Hong Kong, Macao) >=5 years. (2) Meet the diagnostic criteria for prediabetes (fasting plasma glucose 6.1–7.0 mmol/L, or 2-hour plasma glucose 7.8–11.0 mmol/L during an oral glucose tolerance test, or HbA1c 5.7%–6.5%). (3) Daily Lingnan Dietary Index (LDI) score <=50 (assessed by the Lingnan Dietary Frequency Questionnaire). (4) Have not participated in other dietary intervention studies in the past 3 months. (5) Voluntarily sign the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Severe cardiac, hepatic, or renal dysfunction. (2) Digestive system diseases (inflammatory bowel disease, chronic diarrhea, history of gastrointestinal surgery), gout, or severe hyperuricemia. (3) Allergy or intolerance to aquatic products or Lingnan-characteristic vegetables (e.g., bitter melon, okra, etc.). (4) Alcoholism. (5) Use of antibiotics, probiotics/prebiotics, or glucocorticoids within the past 3 months. (6) Pregnancy, lactation, or planning to become pregnant during the study period. (7) Concurrent participation in another clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fasting Plasma Glucose;60-minute Plasma Glucose;120-minute Plasma Glucose;Fasting Insulin;Hemoglobin A1c;Glycated Albumin;Homeostatic Model Assessment of Insulin Resistance;Homeostatic Model Assessment of ß?cell Function; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Creatinine;Blood Urea Nitrogen;Uric Acid;Total Cholesterol;Triglycerides;High?Density Lipoprotein Cholesterol;Low?Density Lipoprotein Cholesterol;Plasma untargeted metabolomics;Fecal untargeted metabolomics;Fecal metagenomics;Determination of serum magnesium; | — |
Countries
China
Contacts
Public ContactDing Gangqiang
Guangdong Provincial Center for Disease Control and Prevention
Outcome results
None listed