None
Conditions
Interventions
Control group2:Tegileridine fumarate combined with sham block
Experimental group:Tegileridine fumarate combined with erector spinae plane block
Control group1:Sufentanil combined with erector spinae plane block
Sponsors
Huaibei Miners General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Able to understand the study purpose, procedures and scale scoring methods; capable of operating PCIA equipment and communicating effectively with researchers. 2.Voluntarily participate in this trial and sign the informed consent form. 3.Scheduled for elective thoracoscopic lung surgery under general anesthesia. 4.Aged from 18 to 75 years old. 5.ASA physical status classification: Grade I–III. 6.Normal preoperative pulmonary function (FEV1/FVC >= 70%). 7.BMI: 18.0–30.0 kg/m^2.
Exclusion criteria
Exclusion criteria: 1.Patients with known or suspected allergy or contraindication to the components of the study drug, other opioids, or other medications specified in the trial protocol; 2.Patients with severe cardiovascular diseases, hepatic or renal insufficiency, mental disorders, or inability to cooperate with pain assessment; 3.Patients with a long-term history of chronic pain; 4.Patients with severe respiratory and circulatory failure occurring during anesthesia and surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Area under the curve of resting NRS pain scores within 48 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting NRS pain scores at postoperative time points;Cumulative opioid consumption within 48 hours after surgery;Time to first rescue analgesia after surgery;Rescue analgesia requirement rate;QoR-15 score;Postoperative time to first ambulation;Postoperative hospital stay;Postoperative inflammatory factor indicators (CRP + PCT); | — |
Countries
China
Contacts
Public ContactSuli Wang
Huaibei Miners General Hospital
Outcome results
None listed