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Development and Validation of a Nomogram for Predicting Anastomotic Leakage After Esophagectomy: Integrating Baseline Characteristics and Early Postoperative Biomarkers

Development and Validation of a Nomogram for Predicting Anastomotic Leakage After Esophagectomy: Integrating Baseline Characteristics and Early Postoperative Biomarkers

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600124666
Enrollment
Unknown
Registered
2026-05-15
Start date
2026-06-01
Completion date
Unknown
Last updated
2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Esophageal Cancer: This is the core primary disease involved in this study, serving as the baseline diagnosis for all enrolled patients.Anastomotic Leakage: This is the specific complication of interest in this study, and the target variable of the predictive model (clinically, it can also be considered a severe postoperative symptom/sign).

Interventions

Observational group:None

Sponsors

Nanjing First Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Patients who underwent esophagectomy for esophageal cancer between January 2020 and December 2025 were enrolled in this study.

Exclusion criteria

Exclusion criteria: 1.neoadjuvant therapy; 2.prior upper gastrointestinal surgery; 3.missing clinical early postoperative biomarkers; 4.incomplete clinicopathological records;

Design outcomes

Primary

MeasureTime frame
Total Pathological Complete Response Rate (tpCR);

Secondary

MeasureTime frame
Breast Pathological Complete Response Rate (bpCR);Objective Response Rate (ORR);Proportion of Patients with Residual Cancer Burden (RCB) Score 0/I;Change in Ki67 Expression Level;

Countries

China

Contacts

Public ContactZhang Aiping

Nanjing First Hospital

apzhdoc68@163.com+86 25 85453092

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 22, 2026