Postoperative delirium
Conditions
Interventions
Cognitive training group:From the time of enrolment, patients will use the ‘Light of the Future’ mobile app to undergo preoperative digital cognitive training. They should train for at least two hours
Control group (routine care group):Routine preoperative preparation and standardized anesthesia management
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: (1) Patients aged over 65 who are scheduled to undergo elective major non-cardiac, non-neurological surgery under general anaesthesia (with an expected duration of more than 2 hours); (2) Have signed an informed consent form; (3) Are able to communicate fluently in Chinese
Exclusion criteria
Exclusion criteria: 1) Life expectancy of less than 6 months; (2) Patients with a history of psychiatric or neurological disorders, such as depression, severe central nervous system depression, schizophrenia, epilepsy, Parkinson’s disease, delirium or Alzheimer’s disease; (3) Patients who are unable to undergo cognitive testing due to blindness, severe deafness, communication difficulties or dementia; (4) Patients routinely taking psychotropic or opioid medications prior to surgery; (5) Patients who have experienced any cerebrovascular event within the past three months, such as a stroke or transient ischaemic attack; (6) Patients with a history of alcohol abuse or withdrawal within the past six months; (7) Patients currently participating in other clinical trials; (8) Patients scheduled to undergo a second surgical procedure within seven days of the planned surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium (POD); | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity and duration of POD;Short-term (1 month) and long-term (6 months) cognitive function scores following surgery;Incidence of postoperative complications, length of hospital stay, and all-cause mortality at 30 days and 6 months;Neuroimaging measures (fMRI functional connectivity strength, DWI white matter integrity);Electrophysiological measures (ERP latency/amplitude, resting-state power spectrum); | — |
Countries
China
Contacts
Public ContactFang Panpan
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed