Adolescent idiopathic scliosis
Conditions
Interventions
Tranexamic acid group:On the evening prior to surgery at 22:30, administer 2 ml of normal saline by intramuscular injection. Fifteen minutes before skin incision, administer 50 mg/kg of TXA intravenou
Bachu Ting Group:On the evening prior to surgery at 22:30, administer 1 U of barbiturate (powder formulation, 1 U/vial) + 2 ml saline solution via intramuscular injection. Fifteen minutes before skin
Sponsors
West China Tianfu Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
10 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Patients aged between 10 and 18 years diagnosed with AIS who underwent PSS surgery; 2. Patients and their families consented to participate in this study and signed the relevant informed consent forms.
Exclusion criteria
Exclusion criteria: 1. Patients with severe underlying cardiovascular or cerebrovascular conditions unsuitable for surgery; 2. Patients with severe anaemia or coagulation disorders prior to surgery; 3. Individuals with allergies to TXA or bartitin; 4. Patients with severe hepatic or renal insufficiency; 5. Those with a history of thrombosis; 6. Patients still taking anticoagulants (such as aspirin) within two weeks prior to surgery; 7. Intraoperative dura mater injury resulting in cerebrospinal fluid leakage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| TBL on the first, second and third days post-surgery;Postoperative blood transfusion rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative blood loss;Occult blood loss;Postoperative fibrinolysis and inflammatory markers;Total postoperative drainage volume;Postoperative hospital stay duration;Postoperative complications; | — |
Countries
China
Contacts
Public ContactLiu Li
West China Tianfu Hospital, Sichuan University
Outcome results
None listed