Chronic Hepatitis B
Conditions
Interventions
Observation group:None
Sponsors
Guabgzhou First People‘s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Patients with chronic hepatitis B aged 18 to 65; 2.After 12 months or more of NAs treatment, HbsAg< 10,000 IU/ml, HbeAg negative, HBV-DNA<100IU/ml; 3.First reception of interferon combined with NAs treatment; 4.Good compliance and voluntary signing of the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Co-infection with other hepatotropic viruses (such as hepatitis A, C, D, and E viruses). 2.Presence of other liver diseases caused by factors like alcoholic liver disease, autoimmune liver disease, or drug-induced liver injury. 3.Severe conditions affecting the heart, kidneys, hematopoietic system, or malignant tumors. 4.Women who are pregnant or breastfeeding. 5.Use of antibiotics, probiotics, immunomodulators, or other medications that may affect gut microbiota and liver function within the past 3 months. 6.All participants with easily confused diseases have been excluded from this study, and the number of relevant confounding cases is 0.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HBsAg level; | — |
Secondary
| Measure | Time frame |
|---|---|
| 16S rRNA indicators(flora a diversity (Shannon, Chao1 index), ß diversity, and differential genus abundance);Metabolomics indicators(Differential metabolite concentrations (e.g., short-chain fatty acids, bile acids, amino acids));ELISA detection index(serum inflammatory cytokines (IL-6, TNF-a, IL-10, TGF-ß) concentration);microRNA indicators(the relative expression levels of differentially expressed microRNAs (e.g., miR-122, miR-155)); | — |
Countries
China
Contacts
Public ContactQi Zhan
Guabgzhou First People‘s Hospital
Outcome results
None listed