gastrointestinal tumor
Conditions
Interventions
Group C:Induction and maintenance of anesthesia using ciprofol
Group P:Induction and maintenance of anesthesia using propofol
Sponsors
Anqing Municipal Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years old, gender not limited; 2. The body mass index (BMI) is between 18 and 30 kg/m^2; 3. ASA classification I to III; 4. Plan to perform elective laparoscopic gastrointestinal surgery; 5. Participate voluntarily and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients who are allergic to eggs, soy products or research drugs (such as ciprofol, propofol, etomidate, midazolam, opioids, rocuronium bromide, etc.); 2. BMI > 30 kg/m^2 or < 18 kg/m^2; 3. There is evidence of preoperative delirium in the preoperative confusion assessment method; 4. Language communication barriers prevent the completion of cognitive function tests; 5. History of neurological and mental disorders: craniocerebral injury, cerebrovascular accident, severe mental disorders, history of cognitive impairment, etc.; 6. History of cardiovascular diseases: uncontrolled hypertension, severe arrhythmia, heart failure, unstable angina pectoris, myocardial infarction, history of severe aortic or mitral valve diseases, etc.; 7. History of respiratory system diseases: respiratory insufficiency, history of obstructive pulmonary disease, acute respiratory tract infection, presence of difficult airways (modified Mallampati score III or IV), etc.; 8. Severe liver and kidney dysfunction (ALT, AST, urea nitrogen, and creatinine levels exceeding the normal values by more than twice); 9. There are severe coagulation dysfunction, serious endocrine diseases or other diseases that affect the hemodynamic state; 10. Abuse or long-term use of anesthetic, sedative and analgesic drugs; 11. Have taken drugs that affect drug metabolism recently; 12. Preoperative systolic blood pressure < 90 mmHg; 13. Patients who have been included in other trial studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of POD within three days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| The quality of recovery three days after the operation;MAP, HR, and BIS values at each time point;Perioperative adverse events (intraoperative awareness, hypertension, hypotension, tachycardia, bradycardia, postoperative nausea and vomiting, hypoxemia, unplanned transfer to ICU);The total amount of intraoperative medication used(Ciprofol, propofol, remifentanil); | — |
Countries
China
Contacts
Public ContactDong Jinchun
Anqing Municipal Hospital
Outcome results
None listed