Knee osteoarthritis
Conditions
Interventions
intervention group:The intervention group will strictly follow the 27-week standardized exercise intervention protocol validated in the research team’s previous studies. This protocol combines "3 week
Retrospective cohort:None
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: Study Population for the Retrospective Cohort Study Inclusion Criteria: 1. Age >= 45 years; 2. BMI >= 24.0 kg/m²; 3. Meets diagnostic criteria for knee osteoarthritis and exhibits symptoms (NRS >= 3); 4. Has completed a 6-month standardized strength training intervention and has complete baseline and post-intervention follow-up data (clinical phenotype and blood samples). Study Participants for the Prospective Cohort Inclusion Criteria: 1. Age >= 45 years; 2. BMI >= 24.0 kg/m²; 3. Meets diagnostic criteria for knee osteoarthritis and exhibits symptoms (NRS >= 3); 4. Is alert and able to cooperate with study interventions and data collection; 5. Provides informed consent and signs the informed consent form.
Exclusion criteria
Exclusion criteria: Study Population for the Retrospective Cohort Exclusion criteria: 1. Age > 75 years; 2. History of total knee arthroplasty; 3. Concurrent severe systemic diseases (e.g., cancer, severe cardiovascular or cerebrovascular disease) or cognitive impairment that precludes participation in the intervention and assessment. Study Population for the Prospective Cohort Exclusion criteria: Same as those for the retrospective cohort.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| knee pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Lower limb muscle strength;balance function;Walking ability;Ability to go up and down stairs;Abdominal muscle endurance;center for epidemiological studies depression scale;Life quility;Bio-omics biomarkers;Knee stiffness;Difficulity in daily activities; | — |
Countries
China
Contacts
Public ContactHongbo Chen
Peking University Third Hospital - Nursing Department
Outcome results
None listed