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Dynamic Evolution of Thyroid Function in ARDS Patients with Different Inflammatory Phenotypes and Its Mediating Role in the Development of ICU-Acquired Weakness: A Prospective Cohort Study

Dynamic Evolution of Thyroid Function in ARDS Patients with Different Inflammatory Phenotypes and Its Mediating Role in ICU-Acquired Weakness: A Prospective Cohort Study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600124627
Enrollment
Unknown
Registered
2026-05-14
Start date
2026-06-01
Completion date
Unknown
Last updated
2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ICU-AW

Interventions

Hyperinflammatory ARDS Phenotype:None
Hypoinflammatory ARDS Phenotype:None

Sponsors

Dazhou Central Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Age >= 18 years old and = 72 hours; 6. Patients or their legal representatives provided written informed consent.

Exclusion criteria

Exclusion criteria: 1. Prior to ICU admission, patients had diseases that clearly caused muscle weakness (such as myasthenia gravis, spinal cord injury, severe hemiplegia after stroke, etc.). 2. Previous history of thyroid disease (hyperthyroidism, hypothyroidism, thyroiditis, etc.) or recent use (within 6 months) of drugs that affect thyroid function (such as amiodarone, lithium, etc.); 3. Severe trauma, burns, or amputation that prevents a limb from being assessed for muscle strength; 4. Long term bedridden (>2 weeks) or with limb dysfunction before admission; 5. Patients who underwent major surgery (especially cardiothoracic surgery, neurosurgery, orthopedic surgery) during or within 4 weeks before admission, which may significantly affect muscle strength assessment or inflammatory response; 6. Pregnant or lactating women; 7. Clinicians judged survival to be less than 24 hours or terminal.

Design outcomes

Primary

MeasureTime frame
Medical Research Council Scale;Bicarbonate;

Secondary

MeasureTime frame
Thyroid function;

Countries

China

Contacts

Public ContactCheng Liu

Dazhou Central Hospital

729599764@qq.com+86 150 8242 8283

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 22, 2026