The occurrence and development of asthma and chronic obstructive pulmonary disease
Conditions
Interventions
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with lung cancer TNM stage IA1 to IIB: aged 18 to 75 years; diagnosed in accordance with the "9th Edition of the International Lung Cancer TNM Staging System" as stage IA1 to IIB; normal lung function; normal lung tissue structure around the cancer lesion as shown on chest CT; lung tissue removed during lung cancer surgery, at least 5 cm away from the cancer lesion; postoperative pathology indicates normal histological phenotype of the adjacent tissue; hemodynamically stable; informed consent obtained from the patient, family members, guardians or legal representatives and signed; 2. Patients with lung cancer TNM stage IA1 to IIB combined with bronchial asthma: aged 18 to 75 years; diagnosed in accordance with the "9th Edition of the International Lung Cancer TNM Staging System" as stage IA1 to IIB and meeting the "2025 Global Initiative for Asthma (GINA) Strategy for the Management and Prevention of Asthma"; positive bronchial dilation test; lung tissue removed during lung cancer surgery, at least 5 cm away from the cancer lesion; hemodynamically stable; informed consent obtained from the patient, family members, guardians or legal representatives and signed; 3. Patients with lung cancer combined with COPD: aged 18 to 75 years; diagnosed in accordance with the "9th Edition of the International Lung Cancer TNM Staging System" as stage IA1 to IIB and meeting the "2025 Global Initiative for Chronic Obstructive Lung Disease (GOLD)"; in a stable clinical state, with no respiratory tract infection or acute exacerbation of COPD in the past 4 weeks; obstructive ventilatory dysfunction indicated by lung function tests; lung tissue removed during lung cancer surgery, at least 5 cm away from the cancer lesion; hemodynamically stable; informed consent obtained from the patient, family members, guardians or legal representatives and signed.
Exclusion criteria
Exclusion criteria: 1. Heart failure (NYHA functional class III or above), arrhythmia or severe coronary artery disease (unstable angina pectoris, myocardial infarction); 2. Coexisting severe liver or kidney diseases and malignant tumors of other organs; 3. Uncontrolled chronic diseases, such as uncontrolled hypertension (resting blood pressure >= 160/100 mmHg), uncontrolled diabetes (random blood glucose > 16.7 mmol/L, glycated hemoglobin > 7.0 %); hemoglobin < 80 g/L; 4. Bleeding disorders, with prothrombin time or activated partial thromboplastin time prolonged by more than 6 seconds compared with the control group; 5. Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diagnosis of thoracic disease;Demographic charateristics; | — |
Countries
China
Contacts
Public ContactZi Chen
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed