Chronic kidney disease sarcopenia
Conditions
Interventions
intervention group:Accept personalized dietary guidance combined with oral nutritional supplements (ONS)
control group:receiving personalized dietary guidance
Sponsors
Huashan Hospital Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age = 18 years old, gender not limited, maintenance hemodialysis treatment = 3 months and stable condition. At least one of the following criteria must be met, defined as the risk of malnutrition or sarcopenia: (1) Serum albumin = 35g/L (2) Body mass index (BMI)5% in the past 3-6 months (3) Skeletal Muscle Index (SMI) meets the criteria for sarcopenia (male<7.0kg/m2 or female<5.7kg/m2) 3. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Uncontrolled malignant tumor (undergoing radiotherapy and chemotherapy), diabetes with poor blood glucose control (HbA1c>9.0%), uncontrolled thyroid dysfunction, and severe liver disease (Child Pugh C) 2. Obesity (BMI>25 kg/m2); 3. 24-hour proteinuria>3.5g; 4. Dialysis adequacy (std Kt/V<2.1); 5. Acute illness (such as severe infection, new cardiovascular and cerebrovascular events), major surgery (abdominal surgery, orthopedic surgery) or trauma occurring within 3 months; 6. Life expectancy<6 months or long-term bed rest; 7. Suffering from diseases that seriously affect digestion and absorption, such as malabsorption syndrome, inflammatory bowel disease, pancreatic dysfunction, etc; 8. Suffering from serious neurological disorders such as stroke, Parkinson's disease, amyotrophic lateral sclerosis, etc., leading to limb dysfunction; 9. Patients who have difficulty swallowing or are allergic or intolerant to the ingredients of the research product; 10. Currently using other nutritional supplements or other nutritional preparations or drugs that may affect the effectiveness of the experiment; 11. Participants in other nutritional intervention clinical trials within the first 30 days of this study; 12. Individuals with cognitive impairment or mental illness (such as depression) are unable to cooperate with the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Skeletal muscle mass index;grip strength; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum albumin;Serum prealbumin;Upper arm muscle circumference;Body Mass Index;6-meter walking speed;SGA rating;KDQOL-SFTM Scale rating;Food Diary; | — |
Countries
China
Contacts
Public ContactJing Qian
Huashan Hospital Fudan University
Outcome results
None listed