Gastric Cancer Disease
Conditions
Interventions
Gold Standard:Tumor Regression Grade
Sponsors
Beijing Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients clinically diagnosed with stage II–IVa gastric adenocarcinoma and adenocarcinoma of the esophagogastric junction (Siewert II/III), confirmed by pathological tissue biopsy; 2. Aged 18–75 years, Eastern Cooperative Oncology Group (ECOG) performance status 0–1; 3. Expected survival >=12 months; 4. No pleural, abdominal, or pelvic effusion, and abdominal-pelvic CT confirms no metastasis to the peritoneum, liver, or other distant organs; 5. Voluntarily willing to sign the informed consent form, demonstrating good compliance and cooperation for follow-up; 6. Intended to receive neoadjuvant drug therapy and undergo radical surgical resection.
Exclusion criteria
Exclusion criteria: 1. Pregnant or breastfeeding women; 2. Those who have received anti-tumor treatment within the past five years; 3. Postoperative pathology indicates positive margins; 4. History of other malignant tumors within the past five years; 5. Uncontrolled pleural effusion, pericardial effusion, or ascites; 6. Severe uncontrolled concurrent infection or other severe uncontrolled comorbidities or diseases that make the subject unfit to participate in the study, or any serious medical disorder that may affect the safety of the subject; 7. Patients requiring emergency surgery, or with complications such as bleeding or obstruction caused by gastric cancer; 8. Clinically severe heart disease or pulmonary dysfunction; 9. Refusal to provide blood or tissue samples; 10. Unable or considered unsuitable for continuing the study due to ethical or medical reasons; 11. Other conditions considered likely to affect patient safety or trial compliance.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Tumor Regression Grade;Disease-free survival;AI-powered pathological data;Accuracy;Specificity; | — |
Secondary
| Measure | Time frame |
|---|---|
| ctDNA Dynamic;Gastric Cancer Disease Monitoring Intelligent Agent; | — |
Countries
China
Contacts
Public ContactXin Ji
Beijing Cancer Hospital
Outcome results
None listed