Hematologic Malignancies
Conditions
Interventions
control group:Daily Activity Education
Intervention Group:Exercise Therapy
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Study participants diagnosed with hematologic malignancies (confirmed by imaging studies, hematologic tests, and pathologic examination) 2. Aged 18–80 years (inclusive) 3. Capable of performing independent light- to moderate-intensity exercise 4. No severe cardiopulmonary dysfunction or other contraindications to exercise 5. No implanted cardiac pacemakers or other metal devices 6. No cognitive impairment and able to complete assessment scales 7. Voluntary participation with signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Untreated unstable bone lesions (especially pathological fractures and spinal cord compression) that cannot tolerate physical stress during exercise (highly increased fracture risk in these areas). 2. Severe cardiopulmonary diseases: Recent (within 6 months) myocardial infarction, stroke, or other major cardiovascular events (unstable angina, aortic stenosis, aortic aneurysm, decompensated heart failure, uncontrolled arrhythmias, chest pain, dyspnea, third-degree heart block). 3. Acute critical illnesses, including acute systemic diseases with deterioration, acute myocardial infarction, acute infections and endocarditis, acute deep vein thrombosis. 4. Presence of severe infections, anemia (hemoglobin <30 g/L), or thrombocytopenia (platelets <10×10^9/L). 5. Severe cognitive impairment or psychiatric disorders that prevent cooperation with scale assessments and exercise therapy. 6. Expected survival <12 months. 7. Current participation in other clinical trials or interventional studies. 8. Concurrent malignancies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| (Multidimensional Fatigute Inventory,MFI)-20;Self-Rating Anxiety ScaleSelf-Rating Depression Scale;(EORTC QLQ-C30);(Timed Up and Go Assessment of Biomechanical Strategies,TUG-ABS);Six Minute Walk Test;(skeletal muscle mass,SMM);(30-Second Chair Stand);Grip strength;Calf circumference; | — |
Secondary
| Measure | Time frame |
|---|---|
| Eastern Cooperative Oncology Group;(Barthel Index of ADL); | — |
Countries
China
Contacts
Public ContactXiang Jie
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed