Adolescent Idiopathic Scoliosis
Conditions
Interventions
Adolescent idiopathic scoliosis patients:none
Parents of adolescents with idiopathic scoliosis:none
Adolescent healthy control group:none
Parents of the adolescent healthy control group:none
Sponsors
Tai'an Central Hospital
Eligibility
Sex/Gender
All
Age
10 Years to No maximum
Inclusion criteria
Inclusion criteria: Inclusion Criteria for Scoliosis Group: 1. Aged 10-18 years, regardless of gender; diagnosed with AIS by EOS full-spine imaging, with a Cobb angle >= 20° and Risser sign 0-2 (skeletally immature); 2. No history of spinal surgery, brace treatment, or long-term antibiotic use (in the past 3 months); 3. Patients and their parents voluntarily participate, sign the informed consent form, and can cooperate with sample collection and follow-up. Inclusion Criteria for the Healthy Group: 1. Aged 10 to 17 years, with gender and BMI matched to the case group, and no family history of spinal-related diseases. 2. Physical examination or EOS full-spine imaging shows a Cobb angle <10°, without spinal deformity or related symptoms. 3. No family history of AIS or other musculoskeletal diseases. 4. No history of antibiotic use in the past 3 months, voluntary participation and signed informed consent form.
Exclusion criteria
Exclusion criteria: Exclusion Criteria for Scoliosis Group: 1. Non-idiopathic scoliosis (such as congenital, neuromuscular, and syndromic types); combined with severe cardiopulmonary diseases, neurological diseases, immunodeficiency diseases, or malignant tumors; 2. Use of antibiotics, probiotics, glucocorticoids, and other drugs that affect intestinal flora or bone metabolism in the past 3 months; history of gastrointestinal surgery, intestinal diseases such as chronic diarrhea/constipation; 3. Lower limb length discrepancy > 1cm, severe foot and ankle deformities (affecting biomechanical assessment); 4. Parents with a history of spinal surgery or severe spinal deformities; those who cannot cooperate with sample collection or follow-up. Exclusion Criteria for the Healthy Group: 1. Same as the case group (excluding the confirmed diagnostic criteria related to AIS).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum metabolites;Intestinal flora sequencing;Plantar pressure;balance function;Gait parameters;Spinal imaging;22-Item Questionnaire Scale of the Scoliosis Research Society; | — |
Countries
China
Contacts
Public ContactZheng Zuncheng
Tai'an Central Hospital
Outcome results
None listed