Pediatric patients requiring sedation for magnetic resonance imaging
Conditions
Interventions
Dexmedetomidine combined with chloral hydrate group (DC group):Forty to fifty minutes prior to the examination, under parental, the child received intranasal dexmedetomidine at a dose of 2 µg/kg and o
Dexmedetomidine combined with midazolam group (DM group):Forty to fifty minutes prior to the examination, the child was calmed by parents and administered 2 µg/kg dexmedetomidine via nasal drops and 0
Dexmedetomidine combined with esketamine group (DE group):Forty to fifty minutes prior to the procedure, the child received intranasal dexmedetomidine at a dose of 2 µg/kg from the same experienced se
Sponsors
Children's Hospital Zhejiang university school of medicine
Eligibility
Sex/Gender
All
Age
No minimum to 1 Years
Inclusion criteria
Inclusion criteria: 1. Children undergoing MRI examination at our hospital, with an anticipated scan duration of 10–45 minutes; 2. Age: 1 month (corrected age for preterm infants >1 month) to 1 year, ASA physical status classification II–III; 3. No history of severe upper airway obstruction; 4. Written informed consent obtained from the child’s parent or legal guardian.
Exclusion criteria
Exclusion criteria: 1. Severe obesity (BMI > 3 standard deviations above the age-specific reference value); 2. History of allergy to sedative medications; 3. Severe systemic diseases: heart failure, hepatic or renal insufficiency; 4. Difficult airway, severe obstructive sleep apnea; 5. Fever (>=38.5°C), purulent sputum, pneumonia; 6. Nasal mucosal injury or gastrointestinal obstruction/reflux; 7. History of arrhythmia, particularly chronic arrhythmia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of delayed awakening;sedation success rate;Overall success rate of sedation;induction time;Parental satisfaction;respiratory depression; | — |
Countries
China
Contacts
Public ContactZhou Xiaqing
Children's Hospital Zhejiang university school of medicine
Outcome results
None listed