Neurocritical illness
Conditions
Interventions
Sequential enteral nutrition group:Sequential enteral nutrition strategy: short-peptide enteral nutrition was administered on days 1–4, followed by whole-protein enteral nutrition from day 5 onward.
Conventional enteral nutrition group:Conventional enteral nutrition: short-peptide enteral nutrition was administered throughout the study period.
Sponsors
Haining People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 86 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18–86 years; 2. Diagnosed with acute neurological diseases, including cerebral hemorrhage, cerebral infarction, and traumatic brain injury; 3. Admitted to the ICU, expected to require enteral nutrition support for >=7 days, with an indication for post-pyloric feeding, and successful placement of a nasojejunal tube confirmed by bedside abdominal X-ray; 4. Voluntarily agreed to participate in the study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Pre-existing severe malnutrition (BMI < 16); 2. Presence of structural gastrointestinal lesions or functional disorders, such as gastrointestinal obstruction or severe gastrointestinal bleeding; 3. Presence of severe multiple organ failure or other diseases that would preclude tolerance of the study intervention; 4. Pregnant or lactating patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in rectus femoris thickness and cross-sectional area; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to achieve nutritional target;Feeding intolerance rate;Length of ICU stay;Total length of hospital stay; | — |
Countries
China
Contacts
Public ContactXiaoxia Li
Haining People’s Hospital
Outcome results
None listed