Postoperative acute pain
Conditions
Interventions
VFIM-PCA group:Variable-rate Feedback Infusion Mode PCA
TBIM-PCA group:Traditional Background Infusion Mode PCA
Sponsors
The First Affiliated Hospital of Zhengzhou University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Age 18–65 years; 2.Body Mass Index (BMI): 18–30 kg/m^2; 3.ASA Physical Status Classification: I–III; 4.Estimated surgical duration less than 5 hours; 5.Scheduled for elective laparoscopic radical surgery for gynecological tumors; 6.No history of previous lower abdominal surgery; 7.Agreement to use Patient-Controlled Intravenous Analgesia (PCIA) postoperatively; 8.The patient and their family members voluntarily agree to participate and have provided written informed consent;
Exclusion criteria
Exclusion criteria: 1.Patients allergic or contraindicated to the investigational drug; 2.Patients with a history of alcohol, sedative-analgesic drugs, psychotropic substances, or drug abuse or addiction; 3.Patients with severe preoperative neurological or psychiatric disorders, language barriers, or other conditions that hinder communication or cooperation; 4.Patients deemed by the investigator to have severe cardiovascular, pulmonary, renal, or hepatic diseases; 5.Patients with preoperative cognitive impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative 24-hour opioid consumption; | — |
Secondary
| Measure | Time frame |
|---|---|
| Effect of pain on mobility at 24 and 48 hours postoperatively;Postoperative 24-hour opioid consumption;Effect of pain on emotional state at 24 and 48 hours postoperatively.;Sleep scores (NRS) at 24 hours, 48 hours, 3 days, 5 days, and 7 days postoperatively;Total amount of rescue analgesics consumed at 24 and 48 hours postoperatively;Postoperative adverse events (nausea, vomiting, dizziness, etc.) at 24 hours, 48 hours, 3 days, 5 days, and 7 days after surgery.;Effect of pain on sleep at 24 and 48 hours postoperatively;Quality of recovery at 24 hours, 48 hours, 3 days, 5 days, and 7 days postoperatively;Feeding tolerance assessment at 24h, 48h, day 3, day 5, and day 7 postoperatively;The lowest and worst pain scores experienced within the first 24 and 48 hours after surgery.;Anxiety and depression scores at 24 hours, 48 hours, 3 days, 5 days, and 7 days postoperatively; | — |
Countries
China
Contacts
Public ContactYingying Zhao
The First Affiliated Hospital of Zhengzhou University
Outcome results
None listed