Sepsis
Conditions
Interventions
Sepsis Patients Group:None
Healthy Control Group:None
Sponsors
Hangzhou First People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Sepsis patient group; 2.Diagnostic criteria: Meet the diagnostic criteria for sepsis or septic shock in the Third International Consensus Definitions for Sepsis and Septic Shock; 3.Age range: 18 years <= age <= 80 years; 4.Time of onset: Enrollment within 48 hours after sepsis diagnosis; 5.Informed consent: Written informed consent voluntarily signed by the patient or their legally authorized representative; 6.Healthy control group:; 7.Health status: No acute or chronic infectious diseases, autoimmune diseases, active malignancies, or severe liver, kidney, or hematological disorders based on health questionnaire and routine physical examination; 8.Age and gender matching: Age matched to the case group (5 years), with similar gender distribution; 9.Informed consent: Written informed consent voluntarily signed by the volunteer;
Exclusion criteria
Exclusion criteria: 1.Patients with major underlying diseases: patients with severe liver cirrhosis (Child–Pugh class C), end-stage renal disease requiring dialysis, New York Heart Association (NYHA) functional class IV heart failure, confirmed hematological malignancies, a history of solid organ or hematopoietic stem cell transplantation, or long-term immunosuppressive therapy. 2.Patients with specific infectious conditions: patients with a confirmed diagnosis of human immunodeficiency virus (HIV) infection or active tuberculosis. 3.Patients with specific physiological or pathological conditions: pregnant or lactating women. 4.Patients with limited feasibility for sample collection: patients from whom an adequate qualified blood sample cannot be obtained due to difficulty in establishing venous access, severe coagulation dysfunction, or other conditions. 5.Other conditions that may interfere with the study results: patients who received leukocyte-containing blood products within 24 hours before enrollment; or any other condition that, in the investigator’s judgment, may affect the assessment of immune function or expose the subject to unacceptable risk.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Organ function indicators;SOFA score;Levels of inflammatory factors (such as IL-6, PCT;28-day mortality rate;APACHE II Score; | — |
Countries
China
Contacts
Public ContactWang Hanbin
Hangzhou First People's Hospital
Outcome results
None listed