Colorectal cancer, sleep fragmentation
Conditions
Interventions
Sleep Fragmentation Group:None
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with rectal adenocarcinoma confirmed by colonoscopy biopsy pathology, who have not received any neoadjuvant chemoradiotherapy, and plan to undergo elective radical surgery; 2. Tumor staging: Preoperative imaging evaluation (chest, abdominal, and pelvic CT/MRI, whole-body PET-CT) confirms no lymph node or distant metastasis (N0M0); 3. Age: 18-75 years old; 4. Gender: no restriction; 5. ASA classification I-III; 6. BMI less than 32 kg/m^2.
Exclusion criteria
Exclusion criteria: 1.Cardiovascular disorders: Patients with cardiac arrhythmias complicated with severe cardio-cerebrovascular diseases (including chronic heart failure, valvular abnormalities, myocardial infarction, recent cerebral infarction, etc.); 2.Respiratory disorders: Patients with dyspnea, respiratory failure, or pulmonary hypertension; 3.Neurocognitive impairment: Patients with mental illnesses or cognitive dysfunction who are unable to cooperate; 4.Other malignancies: Patients with a history of or current other malignant tumors under treatment; 5.MRI contraindications: Patients with absolute contraindications to MRI scanning (such as non-removable metal implants in the body, claustrophobia, etc.); 6.Inability to obtain informed consent: Patients unable to provide signed informed consent;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Density of CD8+ T cell infiltration in tumor tissue; | — |
Secondary
| Measure | Time frame |
|---|---|
| Percentage of CD8+ T cells in peripheral blood; | — |
Countries
China
Contacts
Public ContactChanghong Miao
Zhongshan Hospital, Fudan University
Outcome results
None listed