Induction of Sedation for General Anesthesia in Elderly Patients
Conditions
Interventions
R group:Remazolam induction sedation (sequential dose exploration)
R+E group:Esketamine pre-treatment + Remazolam induction sedation (sequential dose exploration)
Sponsors
General Hospital of the Eastern Theatre of the Chinese People's Liberation Army
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. ASA physical status I–III; 2. Aged 60–80 years; 3. Body mass index (BMI) 18–30 kg/m^2; 4. Scheduled to undergo unilateral total knee arthroplasty under general anesthesia with endotracheal intubation.
Exclusion criteria
Exclusion criteria: 1. Known allergy or contraindication to benzodiazepines or esketamine; 2. Uncontrolled hypertension (defined as resting systolic blood pressure > 180 mmHg or diastolic blood pressure > 110 mmHg); 3. Severe psychiatric illness, severe liver or renal dysfunction; 4. Use of opioids, alcohol, benzodiazepines, or over-the-counter sleep aids; 5. Diagnosed dementia or severe cognitive impairment; 6. Refusal to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ED95 of remimazolam for successful induction sedation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of hypotension during the initial induction observation window;Minimum MAP during the initial induction observation window;Maximum decrease in MAP during the initial induction observation window;Incidence of hypotension during the complete induction-to-intubation observation window;Rate of phenylephrine use;Hemodynamic parameters; | — |
Countries
China
Contacts
Public ContactHui Kangli
General Hospital of the Eastern Theatre of the Chinese People's Liberation Army
Outcome results
None listed