Parkinson's disease
Conditions
Interventions
TMS treatment group:Transcranial magnetic stimulation guided by individual brain function partitioning technology
Closed-loop brain-computer interface implantation group:DBS therapy
Sponsors
Jinan Central Hospital (Capital Medical University Xuanwu Hospital Jinan)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meets the clinical diagnostic criteria of Parkinson's disease by the International Parkinson's Disease Association; 2. Has a definite disabling freezing gait (total score of the New Freezing of Gait Questionnaire = 10); 3. Drug-resistant freezing gait; 4. Hoehn-Yahr stage is in III-IV (open phase); 6. Age between 18 and 80 years old; 7. Montreal Cognitive Assessment Scale score = 24, excluding dementia; 8. Can understand the research content and sign the informed consent form; 9. Has no contraindications for wearing wearable sensors and exoskeleton devices (such as skin ulceration of the lower limbs, severe ankle deformity, etc.), and can cooperate to complete gait data collection.
Exclusion criteria
Exclusion criteria: 1. Secondary Parkinsonism or Parkinsonian superimposed syndrome; 2. Severe internal medical conditions or mental disorders; 3. History of epilepsy, intracranial metal implants, cardiac pacemakers; 4. Presence of MRI or TMS contraindications; 5. Previous DBS surgery and contraindications for DBS or MCS implantation; 6. Suffering from other neurological or skeletal-muscular system diseases that may affect gait;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unified Parkinson's Disease Rating Scale (UPDRSIII) score;Freezing gait;The total duration and occurrence frequency of frozen gait as collected by wearable sensors;Wearable sensors quantify the walking speed, stride length, and gait symmetry; | — |
Secondary
| Measure | Time frame |
|---|---|
| 360-degree turn test;Timing Sit-to-Stand and Walk Test;Narrow Passage Walking Test;Frozen gait diary;Mini Mental State Examination (MMSE) score;Hamilton Depression Scale score;Unified Parkinson's Disease Rating Scale (UPDRSI II IV) score;Montreal Cognitive ; | — |
Countries
China
Contacts
Public ContactZhang Xiaohua, Su Daoqing
Jinan Central Hospital (Capital Medical University Xuanwu Hospital Jinan )
Outcome results
None listed