Endemic arsenic poisoning
Conditions
Interventions
Control group (patients without arsenic poisoning):None
group A (patients with arsenic poisoning):A 6-week multivitamin intervention, followed by a 2-week washout period, and then a 6-week placebo period
group B (patients with arsenic poisoning):A 6-week placebo period, followed by a 2-week washout period, and then a 6-week multivitamin intervention
Sponsors
Inner Mongolia Autonomous Region Center for Disease Control and Prevention (Inner Mongolia Autonomous Region Academy of Preventive Medicine)
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: Participants were chosen from among permanent residents in areas exposed to arsenic, specifically those who had resided there for over a decade and were able to participate in questionnaire surveys and sample collection. An epidemiological link exists between arsenic exposure and poisoning; thus, cases were identified as representative patients with arsenic poisoning from the arsenic-exposed region. Control subjects were selected as permanent residents from the same arsenic-exposed area who did not exhibit arsenic poisoning.
Exclusion criteria
Exclusion criteria: Patients with non-arsenic-related skin diseases, elderly and frail individuals with severe illnesses unable to cooperate with investigations, those with a history of occupational arsenic exposure, and individuals who have consumed seaweed or seafood in the past week.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| urinary arsenic;AFP(Alpha-fetoprotein);CEA(Carcinoembryonic antigen);Thyroid hormones; | — |
Secondary
| Measure | Time frame |
|---|---|
| TC(Total cholesterol);TG(triglycerides);Trace elements in the blood;FBG (fasting blood-glucose); | — |
Countries
China
Contacts
Public ContactZhiwei Guo
Inner Mongolia Autonomous Region Center for Disease Control and Prevention (Inner Mongolia Autonomous Region Academy of Preventive Medicine)
Outcome results
None listed