ischemic stroke
Conditions
Interventions
Experimental group:Low dose (0.225mg/kg) of TNK was given
Standard-care Group:Standard dose of TNK was administered
Sponsors
Ganzhou People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Age >=18 years old; 2. Meet the diagnostic criteria of acute ischemic stroke in the Chinese Guidelines for the Diagnosis and Treatment of Acute Ischemic Stroke 2023; 3. Non-large or middle vessel occlusion confirmed by DSA/MRA/CTA; 4. NIHSS score >=4 and < 25 before thrombolysis; 5. FAST-ED score < 4; 6. Informed consent was signed by the person or legal guardian.
Exclusion criteria
Exclusion criteria: 1. It was clear that the offending vessel was large vessel occlusion and needed endovascular treatment; 2. Intracranial hemorrhage or systemic hemorrhage within 3 months; Other contraindications to intravenous thrombolysis; 3. Severe liver/renal dysfunction: ALT > 3 times normal value at admission /INR > 1.2/ hepatic encephalopathy/previous drug-induced liver dysfunction; Glomerular filtration rate =2 before onset; 5. The predicted survival time of end-stage disease (malignant tumor, end-stage renal disease, etc.) was less than 3 months; 6. Pregnant/lactating period; 7. Other neurological diseases affecting the follow-up neurological function assessment; 8. Oarticipating in other interventional clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| proportion of patients with mRS score 0-1 at 90 days (%);The incidence of symptomatic intracranial hemorrhage (SICH) within 48 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| 90-day EQ-5D-5L scale score;90-day mRS score;The proportion of early improvement in neurological function;Proportion (%) of patients with 90-day mRS score of 0-3 points;Proportion (%) of patients with 90-day mRS score of 0-2 points; | — |
Countries
China
Contacts
Public ContactZeng Guoyong
Ganzhou People's Hospital
Outcome results
None listed