Periampullary Carcinoma:
Conditions
Interventions
Observation group:None
Control group:None
Sponsors
The First Affiliated Hospital of Guangxi Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age between 18 and 85 years 2.ECOG performance status score of 0–1 3.Radiologically confirmed periampullary carcinoma with portal vein-superior mesenteric vein (PV-SMV) invasion but no superior mesenteric artery (SMA) involvement 4.Restored portal venous flow feasible via vascular reconstruction (end-to-end anastomosis, artificial or autologous vascular graft) 5.Voluntarily signed informed consent 6.Discontinuation of preoperative systemic therapy for =4 weeks (=6 weeks for immunotherapy) with no disease progression confirmed radiologically
Exclusion criteria
Exclusion criteria: 1.Pregnancy or lactation 2.Preoperative evaluation showing arterial invasion (e.g., extensive involvement of the superior mesenteric artery or hepatic artery) or distant metastasis, rendering radical resection impossible 3.Severe cardiac, pulmonary, hepatic or renal dysfunction precluding tolerance to surgery and anesthesia 4.Unresectable distant metastasis or second primary malignancy 5.Uncontrolled biliary tract infection or sepsis within 7 days preoperatively 6.Intraoperative findings of extensive peritoneal metastasis or multifocal liver dissemination precluding R0 resection
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall incidence of complications within 30 days postoperatively; | — |
Secondary
| Measure | Time frame |
|---|---|
| Specific postoperative complications included pancreatic fistula, biliary fistula, gastrointestinal anastomotic leakage, intra-abdominal infection, and abdominal cavity Bleeding, pulmonary infection, incision infection, etc;All-cause mortality rates at 30 days and 90 days after the surgery;Intraoperative indicators: operation time, intraoperative blood loss, intraoperative blood transfusion rate;Postoperative recovery indicators included first exhaust time, first feeding time, postoperative hospital stay, ICU admission rate and length of stay.;Oncology indicators included R0 resection rate, number of lymph node dissection and number of positive lymph nodes;Long-term prognosis: disease-free survival (DFS), overall survival (OS);Total cost of hospitalization; | — |
Countries
China
Contacts
Public ContactZhang Wen
The First Affiliated Hospital of Guangxi Medical University
Outcome results
None listed