Metabolic disorders concurrent during pregnancy
Conditions
Interventions
Healthy control group (Part Two):None
Metabolic Disease Only Group (Part Two):None
Typical Comorbidity Pattern Group (Part Two):None
Retrospective study (Part 1):None
Sponsors
Women’s Hospital, Zhejiang University School of Medicine
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for the first part: Single pregnancy; Complete clinical data, with available diagnostic information for major metabolic diseases and basic hematological indicators, complete hospital records and delivery outcome information. 2. Inclusion criteria for the second part: Comply with the corresponding disease diagnostic criteria for each group; Single pregnancy; No history of intestinal diseases or intestinal surgeries; No use of antibiotics, probiotics or immunosuppressants during pregnancy; Voluntary participation and signing of informed consent form.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for the first part: Pre-pregnancy diagnosis of diabetes, chronic hypertension, hyperlipidemia, thyroid disorders, tumors and other chronic underlying diseases; Severe fetal malformations such as congenital heart disease and chromosomal abnormalities; Termination of pregnancy before the second trimester (abortion not due to medical indications), or transfer to another hospital midway and inability to trace the complete medical records. 2. Exclusion criteria for the second part: Infection or inflammation of the gastrointestinal tract; Long-term use of drugs that affect the intestinal flora before pregnancy; Consumption of special diets (such as large amounts of antibiotic foods) within 48 hours before sample collection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Species Composition and Differential Analysis;Analysis of gut microbiota diversity;Functional Genes and Metabolic Pathway Analysis; | — |
Countries
China
Contacts
Public ContactJin Ying
Women’s Hospital, Zhejiang University School of Medicine
Outcome results
None listed