Post-inflammatory Hyperpigmentation (PIH) from Acne Vulgaris
Conditions
Interventions
Control Group:Patients with moderate (Grade III) or severe (Grade IV) acne, receiving oral doxycycline tablets and topical clindamycin phosphate gel, twice daily for 12 weeks.
Experimental Group:Patients with moderate (Grade III) or severe (Grade IV) acne, receiving oral doxycycline tablets, topical clindamycin phosphate gel, and topical mucopolysaccharide polysulfate cream
PIH Treatment Group:Patients who developed PIH after treatment with oral doxycycline tablets and topical clindamycin phosphate gel, receiving topical mucopolysaccharide polysulfate cream, twice daily
Sponsors
The First Affiliated Hospital of Guilin Medical University
Eligibility
Sex/Gender
All
Age
14 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1.Age 14-35 years, male or female. 2.Clinically diagnosed with acne vulgaris according to the "Chinese Guidelines for the Treatment of Acne (2024 Revision)", with facial characteristics meeting the following criteria: 30-75 inflammatory lesions (papules, pustules); 30-100 non-inflammatory lesions (open and closed comedones); and total nodule count = 2. 3.Patients with moderate (Grade III) or severe (Grade IV) acne vulgaris according to the modified Pillsbury classification. 4.Voluntarily participate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Pregnant or lactating female patients. 2.Patients with acne conglobata or acne fulminans. 3.Patients who have received treatment with immunosuppressants, antibiotics, or corticosteroids within 1 month prior to the study. 4.Patients with liver, kidney, hematological, or other visceral diseases. 5.Patients with known allergies to any components of the study medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Melanin Level;Change in Hemoglobin Level;Serious Adverse Events (SAE); | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in Transepidermal Water Loss (TEWL);Change in Stratum Corneum Hydration (SCH);Quality of Life Score;Laboratory Indicators; | — |
Countries
China
Contacts
Public ContactYan Wenjie
The First Affiliated Hospital of Guilin Medical University
Outcome results
None listed