Helicobacter pylori infection
Conditions
Interventions
Vonoprazan Dual-Therapy Group:Vonoprazan Combined with High-Dose Amoxicillin
Kaprazan Dual-Therapy Group:Kaprazan in Combination with High-Dose Amoxicillin
Sponsors
The First Affiliated Hospital of Xiamen University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 70 years. 2.Confirmed H. pylori infection by at least one of the following methods: ¹³C- or ¹4C-urea breath test; immunohistochemical staining of histopathology; H. pylori culture; rapid urease test; stool H. pylori antigen test. 3.Patients undergoing initial (first-line) H. pylori eradication therapy. 4.Willing to undergo H. pylori treatment and having provided written informed consent.
Exclusion criteria
Exclusion criteria: 1.Known allergy or hypersensitivity to any drug used in the treatment regimen. 2.History of gastric surgery or anatomical abnormalities of the gastrointestinal tract. 3.Patients with active peptic ulcer complicated by hemorrhage or presenting with signs indicative of a high risk for gastrointestinal bleeding. 4.Patients with severe dysfunction of major organ systems (e.g., respiratory, cardiac, hepatic, or renal). 5.Use of bismuth preparations, antibiotics, or antibacterial Chinese herbal medicines within 4 weeks prior to enrollment; or use of potassium-competitive acid blockers (P-CABs), proton pump inhibitors (PPIs), H2-receptor antagonists, or non-steroidal anti-inflammatory drugs (NSAIDs) within 2 weeks prior to treatment initiation. 6.Concurrent use of clopidogrel or strong inhibitors/inducers of the cytochrome P450 3A4 (CYP3A4) enzyme. 7.Pregnant or lactating women. 8.Individuals with alcohol abuse, substance addiction, or severe neurocognitive disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of Adverse Reactions;Compliance; | — |
Countries
China
Contacts
Public ContactHuang Weifeng
The First Affiliated Hospital of Xiamen University
Outcome results
None listed