septic cardiomyopathy
Conditions
Interventions
Test group:HA380 haemoperfusion therapy
Control group:Follow the clinician's treatment plan, including cardioversion, intra-aortic balloon counterpulsation (IABP), and extracorporeal artificial membrane lungs (ECMO)
Sponsors
Northern Jiangsu People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients staying in ICU, age >18 years old; 2. Meeting the Sepsis 3.0 diagnostic criteria; 3. Diagnosis of septic cardiomyopathy based on echocardiography (one of the following): (1) left ventricular ejection fraction (LVEF) 11; (3) mitral early peak diastolic velocity/ mitral late peak diastolic velocity (E/A) 2; (4) tricuspid annular plane systolic dilatation (TAPSE) <1.6 cm. TAPSE (Tricuspid Annular Plane Systolic Expansion) <1.6 cm. 4. Have a clinical indication for continuous renal replacement therapy; 5. Obtained informed consent.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to resin, heparin or ichthyosin; 2. Have a history of chronic heart failure; 3. Having a valid diagnosis directly related to myocardial dysfunction, e.g. acute myocardial infarction, myocarditis, unstable angina, post-cardiopulmonary resuscitation status; 4. Terminal status; 5. Those who abandoned treatment during the study period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular ejection fraction;Peak velocity in early mitral diastole / Peak velocity in late mitral diastole;Peak velocity in early diastole of the mitral valve / Peak velocity in early diastole of the mitral annulus;Systolic dilation of the tricuspid annulus; | — |
Secondary
| Measure | Time frame |
|---|---|
| Troponin I;Tumor Necrosis Factor-a;Interleukin-6;Interleukin-1ß;Hemodynamic parameters;Dobutamine dosage;Norepinephrine dosage;Sequential Organ Failure Assessment score;acute physiology and chronic health evaluation scoring system;Number of days of mechanical ventilation;Intensive Care Unit duration;Length of hospital stay; | — |
Countries
China
Contacts
Public ContactLi Xianghui
Northern Jiangsu People's Hospital
Outcome results
None listed