Schizophrenia
Conditions
Interventions
Active HD-tDCS group:Active HD-tDCS
Sham HD-tDCS group:Sham HD-tDCS
Sponsors
Ningbo University Affiliated Kangning Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Meeting the diagnostic criteria for schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); 2.Aged 18–65 years; 3.Right-handed; 4.Stable pharmacological treatment regimen (no dosage adjustments for at least 4 weeks prior to enrollment); 5.No history of neuromodulation treatment within the past 3 months; 6.Clinically stable condition, with no acute exacerbation within the past 3 months.
Exclusion criteria
Exclusion criteria: 1.Comorbid substance use disorders (excluding nicotine), neurological disorders, or other severe psychiatric disorders; 2.Significant behavioral disturbances (e.g., aggression or severe suicidal ideation); 3.Contraindications to brain stimulation (e.g., cardiac pacemaker, intracranial metal implants, or a history of epilepsy); 4.Receipt of electroconvulsive therapy (ECT) within the past 3 months; 5.Severe physical illnesses, infectious diseases, or immune system disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive and Negative Symptom Scale (PANSS) scores;Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Near infrared functional imaging;transcranial magnetic stimulation combined with electromyography (TMS-EMG);Transcranial magnetic stimulation combined with electroencephalography (TMS-EEG);Resting electroencephalography (rsEEG); | — |
Countries
China
Contacts
Public ContactXu Yongming
Ningbo University Affiliated Kangning Hospital
Outcome results
None listed