Esophageal cancer
Conditions
Sponsors
Cancer Hospital Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Male and female patients aged between 18 and 80 years; 2. ASA <= Class III; 3. Body mass index (BMI) < 40 kg/m^2; 4. Elective esophageal cancer radical surgery expected to last at least 3 hours.
Exclusion criteria
Exclusion criteria: 1.Previous history of thoracic or abdominal surgery; 2.History of allergy to general anesthetics; 3.Severe cardiovascular or cerebrovascular dysfunction; 4.Suspected or diagnosed neuromuscular disease; 5.Anticipated requirement for prolonged mechanical ventilation postoperatively; 6.Liver cirrhosis (Child-Pugh class B or C); 7.Chronic renal failure requiring dialysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Recurrent Neuromuscular Blockade (TOFR < 0.9 detected post-extubation); | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of residual neuromuscular block in both groups (failure to achieve TOFR = 0.9 at 10 min after administration of sugammadex 4 mg/kg).;Changes in skeletal muscle area at the L3 level before and after chemotherapy;Skeletal muscle pathological changes in the two groups;Changes in mechanical properties of skeletal muscle cells in both groups;Difference in intraoperative rocuronium dosage between the two groups; | — |
Countries
China
Contacts
Public ContactLi Huixian
Cancer Hospital Chinese Academy of Medical Sciences
Outcome results
None listed