Gastric cancer
Conditions
Interventions
Short-term medication group (3-month group) (600 mg/d):Oral UDCA treatment was initiated after the operation, and the medication was discontinued after continuous use for 3 months.
Mid-term medication group (6-month group) (600 mg/d):Oral UDCA treatment was initiated after the operation, and the medication was discontinued after continuous use for 6 months.
Long-term medication group (12-month group) (600 mg/d):Oral UDCA treatment was initiated after the operation, and the medication was discontinued after continuous use for 12 months.
Sponsors
The Second Hospital & Clinical Medical School, Lanzhou University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 75; 2.It was diagnosed as gastric cancer through pathological examination; 3.Patients who underwent radical gastrectomy (R0 resection) for gastric cancer; 4.Preoperative abdominal ultrasound or CT examination did not detect gallbladder stones or gallbladder diseases; 5.The general condition after the operation is stable and can tolerate oral medication treatment; 6.The expected survival period is greater than 12 months; 7.Voluntarily participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1.There were already gallbladder diseases such as gallbladder stones, cholecystitis or gallbladder polyps before the operation; 2.Previously received cholecystectomy; 3.Patients with severe liver function abnormalities or biliary tract diseases; 4.People allergic to ursodeoxycholic acid; 5.Pregnant or lactating women; 6.Visitors with other severe systemic diseases who are unable to complete the follow-up; 7.The researchers believed that it was not suitable for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of gallbladder stones within 12 months after surgery.; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of gallbladder sludge;The formation time of gallbladder stones;Incidence of gallbladder-related symptoms;The incidence of cholecystitis or cholecystectomy; Incidence of adverse reactions related to UDCA;Analysis of medical expenses and cost-effectiveness at different medication durations; | — |
Countries
China
Contacts
Public ContactHuang Zeping
The Second Hospital & Clinical Medical School, Lanzhou University
Outcome results
None listed