Major Depresssive Disorder
Conditions
Interventions
True stimulation group of depression patients with childhood trauma, sham stimulation group of depression patients with childhood trauma:true stimulation of Stanford Neuromodulation Therapy
sham stimulation group of depression patients with childhood trauma:sham stimulation of Stanford Neuromodulation Therapy
Depression group with childhood trauma:None
Depression group without childhood trauma:None
Healthy control group:None
Sponsors
Hebei Provincial Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Depression group: 1. Meeting the diagnostic criteria for depression in the Diagnostic and Statistical Manual of Mental Disorders (5th Edition), without psychotic symptoms, confirmed by two or more attending psychiatrists; 2. A score of >= 18 on the 17 - item Hamilton Depression Rating Scale (HAMD - 17); 3. Aged between 18 and 60 years, regardless of gender; 4. Right - handed. Healthy control group: 1. Aged between 18 and 60 years, regardless of gender; 2. A score of < 7 on the 17 - item Hamilton Depression Rating Scale (HAMD - 17); 3. Negative trauma results in all dimensions of the Childhood Trauma Questionnaire (CTQ - SF); 4. Right - handed.
Exclusion criteria
Exclusion criteria: Depression group: 1. Meeting the diagnostic criteria for other mental disorders in DSM - 5; 2. Having contraindications for MRI or rTMS; 3. Having a clearly diagnosed neurological disease, such as epilepsy; having comorbid organic brain diseases and a history of severe brain trauma; having severe or unstable physical diseases; 4. Having received rTMS, ECT or light therapy within three months; 5. Being ineffective to ECT treatment (> 8 times); 6. Having previously received antidepressant treatment with implanted devices (DBS, VNS); 7. Being pregnant or lactating women; 8. Having a significant suicide risk (the suicide score of item 3 in HAMD - 17 >= 3 points); 9. Having difficulty in verbal communication and being unable to cooperate with treatment and evaluation. Healthy control group: 1. Having a positive family history of mental illness; 2. Suffering from mental illness, neurological diseases, severe physical diseases, etc.; 3. Being pregnant or lactating women; 4. Having contraindications for magnetic resonance scanning, such as having a cardiac pacemaker.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fractional Anisotropy (FA); | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMD-17 score; | — |
Countries
China
Contacts
Public ContactFan Ziqi
Hebei Provincial Mental Health Center
Outcome results
None listed