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Study on the causes of immune cell aggregation after viral integration into liver cells in children with chronic hepatitis B

Study on the Mechanisms of Immune Cell Infiltration in HBV Integration Sites of Treatment-Naive Pediatric Chronic Hepatitis B Patients with HBeAg Positivity

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600124434
Enrollment
Unknown
Registered
2026-05-12
Start date
2026-05-31
Completion date
Unknown
Last updated
2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic Hepatitis B

Interventions

Observation group:None

Sponsors

The 2nd Affiliated Hospital of Chongqing Medical University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Signed informed consent prior to enrollment and ability to complete the study in accordance with the research protocol; 2.Patients with HBV infection undergoing liver resection; 3.Patients with HBV infection undergoing liver biopsy.

Exclusion criteria

Exclusion criteria: 1.Patients with a definite diagnosis of liver cancer or liver metastases; 2.Patients co-infected with HIV or HCV; 3.Patients with comorbid autoimmune diseases; 4.Pregnant women.

Design outcomes

Primary

MeasureTime frame
Intrahepatic HBV integration;Intrahepatic HBV DNA;HBV-specific T cells;HBV-specific B cells;—

Secondary

MeasureTime frame
Plasma HBV DNA;Intrahepatic pgRNA (pregenomic RNA);Cytokines;Intrahepatic HBsAg (hepatitis B surface antigen);Hepatitis B Serological Markers (HBsAg, anti-HBs, HBeAg, anti-HBe, anti-HBc);Intrahepatic cccDNA (covalently closed circular DNA);Intrahepatic HBV RNA;—

Countries

China

Contacts

Public ContactHong Ren

The 2nd Affiliated Hospital of Chongqing Medical University

renhong0531@vip.sina.com+86 23 63693029

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 22, 2026