Lumbar Disc Herniation
Conditions
Interventions
T1 (Low Glycemic Variability Group): CV = the 33rd percentile (P33):None
T2 (Moderate Glycemic Variability Group): P33 P66:None
Sponsors
Jinling Hospital Affiliated to Nanjing University Medical School
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age 18-75 years, diagnosed with single-segment lumbar disc herniation. 2.Meet the indications for Percutaneous Endoscopic Lumbar Discectomy (PELD) (confirmed by imaging as lumbar disc herniation / failure of conservative treatment). 3. Postoperative follow-up = 3 months, with complete medical records (including Visual Analog Scale [VAS] and Oswestry Disability Index [ODI] scores). 4. Diabetic patients: have a documented history of type 1 or type 2 diabetes (requiring medical record or evidence of glucose-lowering medication use), OR have preoperative fasting plasma glucose =7.0 mmol/L AND glycated hemoglobin (HbA1c) =6.5%. Non-diabetic patients: have no history of diabetes, AND have preoperative fasting plasma glucose <6.1 mmol/L AND HbA1c <5.7%.
Exclusion criteria
Exclusion criteria: 1. History of previous lumbar spine surgery. 2.Presence of systemic diseases that severely impact surgery and prognosis, such as uncontrolled severe cardiopulmonary failure, advanced malignant tumors, severe hepatic or renal dysfunction, etc. 3.Patients with manifestations of cauda equina syndrome, or those with concurrent spinal fractures, tumors, infections, or lower extremity joint diseases — in other words, patients whose condition is not solely attributed to disc herniation. 4. Presence of psychiatric disorders (e.g., schizophrenia, severe depression) that would compromise the patient's ability to cooperate with postoperative follow-up and relevant assessments. 5. Pregnant or lactating women, or patients who have participated in other clinical trials within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improvement Rate of Oswestry Disability Index;Visual Analog Scale (VAS) Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Japanese Orthopaedic Association (JOA) Score;Short Form-36 Health Survey (SF-36) Score;Length of Hospital Stay;Total Analgesic Consumption; Incidence of Postoperative Complications; Incidence of Radiographic Recurrence of Lumbar Disc Herniation; | — |
Countries
China
Contacts
Public ContactYi Jin
Jinling Hospital Affiliated to Nanjing University Medical School( General Hospital of the Eastern Theater Command, People's Liberation Army of China)
Outcome results
None listed