Common Brain Disorders in High-Altitude Regions
Conditions
Interventions
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: This study included four types of high-altitude multiple brain diseases and their corresponding control groups. The inclusion criteria for each group are as follows: 1) Cognitive impairment: Inclusion criteria: a. MMSE cognitive function scale screening=18 years old; c. Sign the informed consent form and be willing to participate in this study. 2) Epilepsy: Inclusion criteria: a. Meet the epilepsy diagnostic criteria of the International League Against Epilepsy (ILAE); b. Age>=18 years old; c. Sign the informed consent form and be willing to participate in this study. 3) Migraine: Inclusion criteria: a. Study participants who meet the migraine diagnostic criteria of the American Headache Association (ICHD-III); b. Age>=18 years old; c. Sign the informed consent form and be willing to participate in this study. 4) Sleep disorders: Inclusion criteria: a. Meets the diagnostic criteria for chronic insomnia and short-term insomnia in the International Classification of Sleep Disorders, Third Edition (ICSD-3); b. Age>=18 years old; c. Sign the informed consent form and be willing to participate in this study; d. According to the researcher's judgment, it is not suitable to participate in this clinical trial;
Exclusion criteria
Exclusion criteria: This study included four types of high-altitude multiple brain diseases and their corresponding control groups, with the following exclusion criteria for each group: 1) Cognitive impairment: Exclusion criteria: a. Cognitive impairment caused by normal pressure hydrocephalus and other diseases (such as traumatic brain injury or surgery, infection, immunity, tumors, poisoning, and metabolic diseases); b. Existence or past Suffering from Parkinson's disease or mental illnesses such as schizophrenia, bipolar disorder, severe depression or anxiety; c. Serious dysfunction of important organs (heart, lungs, liver, kidneys, etc.), malignant tumors, etc; d. According to the researcher's judgment, it is not suitable to participate in this clinical trial; 2) Epilepsy: Exclusion criteria: a. Presence of mental disorders, drug or substance abuse, or other mental illnesses or sleep disorders caused by drugs; b. Suffering from serious chronic physical diseases or neurological tumors; c. Not willing to participate in this project researcher; d. According to the researcher's judgment, it is not suitable to participate in this clinical trial; 3) Migraine: Exclusion criteria: a. Presence of mental disorders, drug or substance abuse, or other mental illnesses or sleep disorders caused by drugs; b. Suffering from serious chronic physical diseases or neurological tumors; c. Not willing to participate in this project researcher. 4) Sleep disorders: Exclusion criteria: a. Presence of mental disorders, drug or substance abuse, or other mental illnesses or sleep disorders caused by drugs; b. Suffering from serious chronic physical diseases or neurological tumors; c. Not willing to participate in this project researcher; d. According to the researchers' judgment, it is not suitable to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognitive related biomarkers (p-tau217, A ß 42/40, etc.);Echocardiography and Right Heart Contrast Echocardiography;Functional Near-Infrared Spectroscopy (fNIRS);MRI;EEG;Gastrointestinal electricity;Transcriptomics ;eye movement;Neuropsychiatric Scale;Clinical information; | — |
Secondary
| Measure | Time frame |
|---|---|
| Basic Community Information;Blood routin;Blood chemistry;blood pressure;Therapeutic Level Monitoring for Epilepsy;Reproductive Endocrine Hormone Testing;Wearable Devices; | — |
Countries
China
Contacts
Public ContactLei Chen
West China Hospital, Sichuan University
Outcome results
None listed