Breast cancer
Conditions
Interventions
Experimental group:Preoperative and postoperative nerve block with liposomal bupivacaine in patients undergoing breast cancer surgery.
Control group:Routine preoperative and postoperative analgesia in patients undergoing breast cancer surgery.
Sponsors
The First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
Female
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Confirmed breast cancer patients aged <=80 years. 2. Patients with preoperative American Society of Anesthesiologists (ASA) physical status classification I–III. 3. No evidence of metastasis to organs or tissues beyond the breast, with or without ipsilateral local lymph node metastasis (i.e., T1–4, N0–1, M0). 4. Undergoing unilateral mastectomy, with or without lymph node dissection.
Exclusion criteria
Exclusion criteria: 1. Patients with a previous history of malignant tumors or prior surgery for malignancy. 2. Patients with a prior history of severe cardiovascular or cerebrovascular events, such as myocardial infarction or cerebrovascular accident (stroke), with significant sequelae. 3. Patients with a previous history of allergy to bupivacaine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of perioperative pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anesthesia recovery status;Incidence of chronic postoperative pain;Postoperative local or metastatic recurrence of breast cancer;Intraoperative hemodynamic changes; | — |
Countries
China
Contacts
Public ContactXie Yanhu
The First Affiliated Hospital of University of Science and Technology of China
Outcome results
None listed