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iTBS regulates the brain network mechanism of M1/DLPFC to improve the efficacy of MI-BCI in patients with stroke upper limb disorders

iTBS regulates the brain network mechanism of M1/DLPFC to improve the efficacy of MI-BCI in patients with stroke upper limb disorders

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600124411
Enrollment
Unknown
Registered
2026-05-12
Start date
2026-06-01
Completion date
Unknown
Last updated
2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

DLPFC Group:Transcranial Magnetic Stimulation iTBS+ brain-computer interface training
M1 Group:Transcranial Magnetic Stimulation iTBS+ brain-computer interface training
Sham Group:Transcranial Magnetic Stimulation sham iTBS+ brain-computer interface training

Sponsors

Guangdong Provincial Hospital of Traditional Chinese Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. In line with the "China cerebrovascular disease prevention and control guidelines" diagnostic criteria, the course of the disease >= 1 month; 2. One-sided upper limb motor dysfunction (Brunnstrom staging I-IV); 3. simple intellectual state examination (MMSE) 10-30 points, right hand, age 50-75 years old; 4. Voluntary signing of informed consent.

Exclusion criteria

Exclusion criteria: 1. There has been a history of upper limb fracture, upper limb deformity, etc.; 2. The disease is unstable or the disease changes during the experiment, affecting the experimental results; 3. Combine serious heart, lungs, liver and kidney diseases and other important organ diseases and can not complete the experiment; 4. People with severe cognitive impairment or aphasia; 5. Persons with severe mental disorders; 6. Those who are taking antiepileptic drugs; 7. Previously implanted metal devices, affected by magnetic fields stimulated by cranial magnetic.

Design outcomes

Primary

MeasureTime frame
BCI Decoding Accuracy;Performance Assessment Scale – Fugl-Meyer;Brain network topology;

Secondary

MeasureTime frame
Montreal Cognitive Assessment;Ability to perform activities of daily living;

Countries

China

Contacts

Public ContactHaining Ou

Guangdong Provincial Hospital of Traditional Chinese Medicine

Haining@gzucm.edu.cn+86 186 8890 6213

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 22, 2026