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A Long-term Follow-up Retrospective Study of Zebetuximab/Rituximab Combined with CHOP (HI-CHOP/R-CHOP) in the Treatment of Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)

A Long-term Follow-up Retrospective Study of Zebetuximab/Rituximab Combined with CHOP (HI-CHOP/R-CHOP) in the Treatment of Newly Diagnosed Diffuse Large B-Cell Lymphoma (DLBCL)

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600124408
Enrollment
Unknown
Registered
2026-05-12
Start date
2026-05-19
Completion date
Unknown
Last updated
2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diffuse large B-cell lymphoma

Interventions

Observation group:N/A

Sponsors

Sun Yat-sen University Cancer Center
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1.Histologically confirmed CD20-positive, previously untreated diffuse large B-cell lymphoma, not otherwise specified (DLBCL-NOS); 2.Received first-line treatment with either the Hi-CHOP regimen (Zercepac 375 mg/m^2 + CHOP, q3w, >= 3 cycles) or the R-CHOP regimen (Rituximab 375 mg/m^2 + CHOP, q3w, >= 3 cycles). 3.Age and gender are not restricted. 4.Complete survival follow-up and adequate data availability can be achieved prior to study initiation.

Exclusion criteria

Exclusion criteria: 1.Key data on demographic information and medication information are missing. 2.Survival data are missing or the patient refused survival follow-up. 3.The investigator determined that other ineligible conditions exist (e.g., concomitant other malignancies, non-standard treatment regimens, etc.).

Design outcomes

Primary

MeasureTime frame
5-year Overall Survival (OS) Rate;

Secondary

MeasureTime frame
5-year progression-free survival (PFS) rate;Secondary Endpoint;4-year Progression-Free Survival (PFS) Rate;

Countries

China

Contacts

Public ContactLi Zhiming

Sun Yat-sen University Cancer Center

lizhm@sysucc.org.cn+86 20 87343765

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 22, 2026