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Mechanism of APOL1 in Promoting M1 Macrophage Polarization in Necrotizing Enterocolitis

Mechanism of APOL1 in Promoting M1 Macrophage Polarization in Necrotizing Enterocolitis

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600124405
Enrollment
Unknown
Registered
2026-05-12
Start date
2025-07-30
Completion date
Unknown
Last updated
2026-05-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Necrotizing enterocolitis, NEC

Interventions

NEC group:None
Control group:None

Sponsors

Guangdong Women and Children Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. NEC patients receiving treatment in our hospital; 2. Clinical and postoperative pathological diagnosis of NEC.

Exclusion criteria

Exclusion criteria: 1.Those whose diagnoses are unclear or who have given up on treatment

Design outcomes

Primary

MeasureTime frame
Expression levels of APOL1 in plasma and intestinal tissues of different groups;—

Secondary

MeasureTime frame
The mechanism by which APOL1 regulates the TLR4/NF-?B signaling pathway to promote M1 polarization of macrophages;—

Countries

China

Contacts

Public ContactTian Song

Guangdong Women and Children Hospital

874620478@qq.com+86 20 3915 1815

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 22, 2026