Cerebral small vessel disease (CSVD)
Conditions
Interventions
Primary Motor Cortex + Cerebellar Target Group:Transcranial Magnetic Stimulation
Sham TMS Group:Transcranail Magnetic Stimulation
Primary Motor Cortex Target Group:Transcranial Magnetic Stimulation
Cohort Study Group:None
Sponsors
The First Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Present with at least one of the imaging diagnostic markers of CSVD according to the Chinese Guidelines for Diagnosis and Treatment of Cerebral Small Vessel Disease 2020; 2. Aged >=18 years; 3.Provide signed informed consent.
Exclusion criteria
Exclusion criteria: 1.Stenosis >=50% of the cervical and/or intracranial large arteries (basilar artery, vertebral artery, anterior cerebral artery, middle cerebral artery (M1–M2 segments), and posterior cerebral artery) diagnosed by ultrasound or imaging; 2. Acute non-lacunar ischemic stroke occurring within the past 30 days, or a pre-existing cerebrovascular disease that has resulted in functional disability with a modified Rankin Scale (mRS) score >=2; 3. Intracranial hemorrhagic lesions (including cerebral hemorrhage, subarachnoid hemorrhage, epidural/subdural hemorrhage, etc.), traumatic brain injury, cerebral vascular malformation, or aneurysm occurring within the past 30 days; 4. Presence of severe systemic disease, cancer, or trauma; 5. Presence of other causes of neurological dysfunction (e.g., poisoning, alcohol abuse, drug addiction, epilepsy, encephalitis, or normal-pressure hydrocephalus); 6. Presence of other neurodegenerative diseases (e.g., Alzheimer's disease, Parkinson's disease) or non-vascular white matter diseases (e.g., multiple sclerosis, inflammation, tumors, adult-onset leukodystrophy, metabolic encephalopathy); 7. Presence of psychiatric disorders or severe depression; 8. Severe impairment of vision, hearing, language function, or limb muscles, or inability to cooperate with examination personnel, precluding completion of relevant assessments; 9. Contraindications to MRI scanning for any reason (e.g., claustrophobia, implanted pacemaker, etc.) or poor MRI image quality; 10. Pregnancy or breastfeeding; 11. Unwillingness to receive follow-up or poor treatment adherence.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gait Analysis;Magnetic Resonance Imaging; | — |
Secondary
| Measure | Time frame |
|---|---|
| Near-infrared Funcitonal Brain Imaging;Clinical Symptom Assessment;Eye Tracker; | — |
Countries
China
Contacts
Public ContactBingwei Zhang
The First Affiliated Hospital of Dalian Medical University
Outcome results
None listed